Antifungal Screening of Surveyed Plants of Gwadabawa/Illela Communities of Sokoto State-Northwest Nigeria

Pharmacognosy Research,2022,14,4,417-422.DOI:10.5530/pres.14.4.61Published:October 2022Type:Original ArticleAuthors:Mathias Sylvester Nefai, Mshelia Halilu Emanuel, Giaze Tijani Rabiu, and Hussain Yahaya Ungo-Kore Author(s) affiliations:Mathias Nefai1,*, Emanuel2, Rabiu3, Ungo-Kore4 1Department of Ethnopharmacy, Usmanu Danfodiyo University, Sokoto-NIGERIA. 2Faculty Pharmacy, Cyprus International Haspolat/Nicosia, Mersin, TURKEY. 3Department Pharmacology Toxicology, 4Department Pharmaceutical Microbiology, Abstract:Background: An earlier ethnobotanical study afforded fifteen surveyed plants, which are used as antifungal wound healing remedies. This informed their screening to validate folklore claims. Materials Methods: Identified, procured, authenticated medicinal plants were each, defatted in hexane extracted with methanol before partitioning n-butanol obtain an extract solubilized compounds the organic phase. The resulting concentrated extracts then screened by subjecting each plant vitro assay for determination minimum inhibitory concentration (MIC) on Aspergillus niger a 96-well flat bottom polystyrene microtiter plate using broth microdilution method outlined 2021 Clinical Laboratory Standard Institute guideline. Results: presented active variable properties MIC values ranging from 3.9 250 (mg/ml). Only Balanites aegyptica showed no activity at all concentrations tested. lowest extreme was recorded Ficus Platyphylla, gave slight highest 125mg/ml, while Faidherbia albida test 3.90625 mg/ml. other thirteen exhibited varying degree following MICs: Stecullia setigera (7.8125 mg/ml), Annona senegalensis Uraria picta mg/ml) Combretum collinum (15.65 Afromosia lexiflora Waltheria indica Guiera Carica papaya (31.25 Rogeria adenophylla Pennisetum hordeoides Acacia nilotica Sida ovata (62.5 mg/ml). Conclusion: potential these supports traditional use, hence, information (data) furnished this can be exploited further evaluations antimicrobial drug leads nature. Keywords:Antifungal remedy, albida, Gwadabawa/Illela, Plant extract, Surveyed plantsView:PDF (602.32 KB)